Warring Alien and Predator races descend on a rural Colorado town, where unsuspecting residents must band together for any chance of survival.

Meanwhile, another Predator lands seeking out the Alien and destroying evidence of their presence on Earth. The dwellers of the town find themselves in the middle of a battlefield between the two deadly extraterrestrial creatures, and the small group of survivors splits between the leadership of Sheriff Eddie Morales and the bad-boy Dallas Howard. Both have different opinions about the best means to escape from the beings.