Chris Flynn is driving through the backwoods of West Virginia on the way to an interview when he has an accident with a group of five friends, writing off his car. Their car is also damaged, so four of them set off to find help, leaving two behind to watch the cars. One by one they get picked off by a bunch of mutated inbred hillbillies.

Six people find themselves trapped in the woods of West Virginia, hunted down by “cannibalistic mountain men grossly disfigured through generations of in-breeding.”