Bodies are turning up around the city, each having met a uniquely gruesome demise. As the investigation proceeds, evidence points to one suspect: John Kramer, the man known as Jigsaw, who has been dead for over 10 years.

When Dan finds a tape with the voice of the killer, he invites Hoffman and Perez to go with him to the laboratory to see the progress with the identification of the real voice. John’s widow Jill Tuck receives a box from his lawyer with six envelops with instructions and she gives the first five to Hoffman. The unethical CEO of the Umbrella Health, William Easton, and his team are abducted and William is forced to play a game and choose who will live or die to save his family and him.

Special Agent Peter Strahm is suspicious of him after his assistant Agent Lindsay Perez says Hoffman’s name. While Agent Strahm looks into Detective Hoffman’s past, a group of five people who helped burn a building which was supposedly abandoned, face a series of tests set up by Jigsaw.