When Dominic Toretto is informed that his beloved Letty was assassinated, he returns to Los Angeles to find the murderer. Meanwhile, his former friend and FBI agent Brian Conner are assigned to capture the mysterious drug lord Braga that is looking for replacement drivers, working undercover as his courier, driving from Mexico to the USA through the desert.

Dom discovers that Letty was working as a courier for Braga when she was killed and he decides to join his gang to find the killer. Their lives entwine substantiating their friendship and Brian dates Mia Toretto again. But they need to find the true identity of Braga.