Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity’s final stand against the undead. Now, she must return to where the nightmare began – The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

Alice receives crucial information about the imminent elimination of the rest of humanity from an unlikely source and with the help of a few survivors embarks on a perilous journey to The Hive in Raccoon City to stop it, all the while fighting off infected creatures as well as agents of the Umbrella Corporation.