Alice awakes at home with her daughter Becky and her husband. But soon she realizes that she is actually in an Umbrella Corporation’s underground facility. Out of the blue, the computer security system shuts-down and Alice flee to the central control room of the facility. She meets Ada Wong, who works with Albert Wesker, and she learns that a five-man team has been sent by Wesker to rescue them. However, the Red Queen sends Jill Valentine and Rain to hunt them down.

The Umbrella Corporation’s deadly T-virus continues to ravage the Earth, transforming the global population into legions of the flesh-eating Undead. The human race’s last and only hope, Alice, awakens in the heart of Umbrella’s most clandestine operations facility and unveils more of her mysterious past as she delves further into the complex.