Alice, having escaped from the Umbrella facility, finds Raccoon City overrun with the undead. Along with a group of survivors that includes Jill Valentine, she must find the daughter of Dr. Charles Ashford, who will then provide them with a way out of the city before it is nuked by Umbrella in a cover-up attempt. Meanwhile, they are being hunted by the Nemesis, another one of Umbrella’s experiments.

Alice awakes in Raccoon City, only to find it has become infested with zombies and monsters. With the help of Jill Valentine and Carlos Olivera, Alice must find a way out of the city before it is destroyed by a nuclear missile.