Jack Sparrow, along with the feared pirate Edward Teach aka Blackbeard and a mysterious woman from his past, race to the infamous Fountain of Youth. Meanwhile, the Spanish have sent some ships to go looking for the Fountain, and to counter them, the English have sent their own ship under the captainship of the pirate-turned-privateer Hector Barbossa.

While Blackbeard is seeking the Fountain to Save his own skin, Barbossa has a vendetta of his own. Who will be the one to reach the Fountain of Youth before the others? Jack Sparrow and Barbossa embark on a quest to find the elusive fountain of youth, only to discover that Blackbeard and his daughter are after it too.