After an excoriating official US government review of its history of questionable missions with high stakes and considerable collateral damage, the IMF is disbanded. Regardless, Ethan Hunt is undeterred from his personal mission to stop a sinister counter-organization to the IMF, the Syndicate.

Now a fugitive from the CIA, Hunt secretly calls his colleagues together to accomplish that, which soon also involves a mysterious woman who has an agenda of her own with those criminals. With both sides playing deadly complex games of intrigue, Hunt and his team must take even more risk with difficult options to protect the world.