Woody, Buzz and the whole gang are back. As their owner Andy prepares to depart for college, his loyal toys find themselves in daycare where untamed tots with their sticky little fingers do not play nice. So, it’s all for one and one for all as they join Barbie’s counterpart Ken, a thespian hedgehog named Mr. Pricklepants and a pink, strawberry-scented teddy bear called Lots-o’-Huggin’ Bear to plan their great escape.

With their beloved Andy preparing to leave for college, Woody, Buzz Lightyear, Jessie, and the rest of the toys find themselves headed for the attic but mistakenly wind up on the curb with the trash. Woody’s quick thinking saves the gang, but all but Woody end up being donated to a day-care center. Unfortunately, the uncontrollable kids do not play nice, so Woody and the gang make plans for a great escape.